Immuno-Oncology Core
The Immuno-Oncology (I-O) Core works directly with clinical investigators to design, execute, and analyze correlative studies to gain mechanistic insights into immuno-oncology clinical trials. The core provides unique services as well as works with other cores on resources that are already available at City of Hope.
I-O Core-specific services include:
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High-parameter (six-marker) multiplex immunofluorescence of formalin fixed tissue samples using a spectral imaging system (Akoya Ve<:tra 3.0). We provide quantitative spatial image analysis using machine-learning approaches for cell phenotyping and tissue segmentation, which enable cell density calculations and a variety of spatial interaction metrics.
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High-parameter flow cytometry for complex immune subset proHing of dinical tissue samples. These assays utilize the Cytek Aurora spectral cytometer in the Analytical Cytornetry Core.
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Expertise on study design, protocol development, proposal approval, experimental execution, sample management, research data generation, analysis and publication, and database and infonnatics for cancer immunotherapy dinical trials.
Current pricing can be found on iLab Solutions.
The Vectra 3 automated quantitative pathology imaging system provides multispectral and automated multi-slide imaging of up to six slides to detect and measure weakly expressed and overlapping biomarkers in H&E, IHC or IF intact FFPE tissue sections or TM
Colt Egelston
Core Manager
cegelston@coh.org
Chi Hoang
Research Associate I
choang@coh.org
Oscar Flores
Research Associate II
ocolungaflores@coh.org
In a given year, City of Hope conducts more than 400 clinical trials enrolling more than 6,000 patients.
City of Hope is focused on basic and clinical research in cancer, diabetes and other life-threatening diseases.
