Ke Ma, M.D., Ph.D.
2003, Ph.D., Cardiovascular Sciences, Baylor College of Medicine
1997, MS, Cardiology, Shandong Medical University
1989-1994, M.D., Medicine, Shandong Medical University
1997-2002, Graduate Student, Lipoprotein Metabolism, Baylor College of Medicine
2004-2009, Molecular Endocrinology, Baylor College of Medicine
2003-2004, Lipoprotein Metabolism, Baylor College of Medicine
2017-present, Associate Professor, Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA
2016-2017, Assistant Professor, Molecular and Cellular Biology, Baylor College of Medicine, Waco, TX
2010-2016, Assistant Member, Center for Diabetes Research, Houston Methodist Research Institute, Houston, TX
The broad goal of Dr. Ma’s research is to decipher the molecular pathways by which cell-autonomous clock circuits drive metabolic tissue growth and functional capacity, in order to uncover circadian etiologies underlying metabolic disorders for targeted therapeutic interventions. By combining biochemical and molecular biology approaches with whole-body animal physiology, Dr. Ma’s laboratory applies state-of-the-art technologies in circadian biology to metabolic disease research. In the past seven years, Dr. Ma has successfully established a unique research program in dissecting temporal mechanisms involved in tissue growth and functions of distinct adipose depots and skeletal muscle.
Currently, Dr. Ma’s lab is investigating the genetic and epigenetic regulatory networks mediating nutrient-sensing functions of clock in tissue crosstalk between fat, muscle and liver under normal physiology, and more importantly, how there mechanisms apply to obesity and diabetes. Furthermore, her group explores how clock systems drive stem cell behaviors to fine-tune tissue development, growth and remodeling, and how these processes impact their metabolic capacity. In addition, Dr. Ma will establish collaborative effort with investigators from translational medicine and the Comprehensive Cancer Center at City of Hope to study how environmental lighting and shiftwork-induced circadian clock disruption leads to metabolic dysregulations and its causal relationship with the development of various types of cancer. Ultimately, Dr. Ma’s research to decipher the intricate temporal mechanisms will lead to the discovery of novel targeted clock interventions for the prevention or treatment of metabolic diseases and cancer.
2005, AstraZeneca Diabetes and Metabolism Research Fellow Award, The Endocrine Society
2003, Mason Guest Memorial Award in Physiology & Biophysics, 44th National Student Research Forum
2003, AstraZeneca Diabetes and Metabolism Research Fellow Award, The Endocrine Society
2003, Research Excellence Award, Society of Chinese Bioscientists in America
2006-Present, American Heart Association
2010-Present, American Diabetes Association
2014-Present, American Physiology Society
2006-2012, The Endocrine Society
- Nam, D., Yechoor, V.K. and Ma, K. Molecular clock integration of brown adipose tissue formation and function. Adipocyte DOI:10.1080/21623945. 2015;10820153.
- Nam, D., Chatterjee, S., Yin, H., Liu, R., Lee, J., Yechoor, V.K., and Ma, K. Novel function of Rev-erb α in promoting brown adipogenesis. Sci Rep. 2015 Jun 10;5:11239.
- Nam, D., Guo, B., Chatterjee, S., Chen, M.H., Fang, Z., Nelson, D., Yechoor, V.K., and Ma, K. The adipocyte clock controls brown adipogenesis through the TGF-β and BMP signaling pathways. J Cell Sci. 2015 May 1;128(9):1835-47
- Chatterjee, S., Nam, D., Guo, B., Kim, J.M., Winnier, G.E., Lee, J., Berdeaux, R., Yechoor, V.K., and Ma, K. Brain and Muscle Arnt-like 1 is a key regulator of myogenesis. J Cell Sci. 2013 May 15;126(Pt 10):2213-24.
- Guo, B., Chatterjee, S., Li, L., Kim, J.M., Lee, J., Yechoor, V.K., Minze, L.J., Hsueh, W., and Ma, K. The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J. 2012 Aug;26(8):3453-63
- Huang, W., Ma, K., Zhang, J., Qatanani, M., Cuvillier, J., Liu, J., Dong, B., Huang, X., and Moore, D.D. Nuclear receptordependent bile acid signaling is required for normal liver regeneration. Science. 2006 Apr 14;312(5771):233-6.
- Ma, K., Saha, P.K., Chan., L., and Moore, D.D. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006 Apr;116(4):1102-9.